Anterior nuclear group (important part of the Papez circuit) is made up of 3 subnuclei (anteroventral, anterodorsal, and anteromedial) connected to the hippocampal formation by cingulum bundle. The anteroventral subnuclei is the largest among the 3. Main inputs to the anterior nuclear group arise from the subiculum, presubiculum, parasubiculum, anterior/posterior cingulate cortices, retrosplenial cortex, inferior parietal lobule and hippocampal CA1. Like other thalamic nuclei, the anterior nuclear group has 2 distinct patterns of firing: tonic and burst. These neurons may also be important for propagation of the theta rhythm, important for hippocampal synaptic plasticity and may also have functions in seizure propagation and prion diseases.